Infectious Diseases
Family: Herpesviridae
Genus: Lymphocryptovirus
Infectious mononucleosis is an acute lymphoproliferative disease that is common in children and young adults and is caused by the Epstein Barr Virus (EBV). The EBV is one of the herpes viruses 4 (gamma). Characteristic clinical features include:
1. fever, sore throat, and lymhadenopathy
2. an associated absolute lymphocytosis greater than 50%, containing at least 10% of atypical lymphocytes in the peripheral blood
3. development of transient heterophil and persistent antibody responses against EBV
4. abnormal liver function tests
4% of infected young adults show an icteric manifestation and 50% have splenomegaly. In addition, EBV is implicated in nasopharyngeal carcinoma, Burkitt lymphoma and Hodgkin´s disease.
The different stages of an EBV infection (acute, reactivated, past) are characterized by the appearance of different antibodies (IgA, IgG, IgM) against different viral antigens (virus Capsid antigen = VCA, early antigen = EA and Epstein-Barr Virus nuclear antigen = EBNA). The parameters produced by IBL enable to detect and differentiate all stages of an EBV infection. A well directed selection of antigens for IBL EBV ELISAs results in an extraordinary sensitivity and specificity for the diagnosis of acute diseases and for the detection of past infections.
Genus: Lymphocryptovirus
Infectious mononucleosis is an acute lymphoproliferative disease that is common in children and young adults and is caused by the Epstein Barr Virus (EBV). The EBV is one of the herpes viruses 4 (gamma). Characteristic clinical features include:
1. fever, sore throat, and lymhadenopathy
2. an associated absolute lymphocytosis greater than 50%, containing at least 10% of atypical lymphocytes in the peripheral blood
3. development of transient heterophil and persistent antibody responses against EBV
4. abnormal liver function tests
4% of infected young adults show an icteric manifestation and 50% have splenomegaly. In addition, EBV is implicated in nasopharyngeal carcinoma, Burkitt lymphoma and Hodgkin´s disease.
The different stages of an EBV infection (acute, reactivated, past) are characterized by the appearance of different antibodies (IgA, IgG, IgM) against different viral antigens (virus Capsid antigen = VCA, early antigen = EA and Epstein-Barr Virus nuclear antigen = EBNA). The parameters produced by IBL enable to detect and differentiate all stages of an EBV infection. A well directed selection of antigens for IBL EBV ELISAs results in an extraordinary sensitivity and specificity for the diagnosis of acute diseases and for the detection of past infections.
| Catalog number | RE57351 |
| Kit size | 12 x 8 |
| Method / Technology | ELISA |
| Incubation time | 2 x 1 h, 1 x 30 min |
| Standard range | 2 - 200 U/ml |
| Specimen / Volumes | 5 µL serum, plasma |
| Substrate / isotope | TMB 450 nm |